Heterogeneity of reactive astrocytes
نویسندگان
چکیده
منابع مشابه
Diversity in Reactive Astrocytes
Normal astrocytes in the adult undergo hypertrophy and proliferation and transform into reactive astrocytes following many types of central nervous system (CNS) injury (1–5). This process is termed astrogliosis and may result in the formation of a glial scar. Morphological studies on astrogliosis by neuroanatomists and pathologists at the beginning of this century focused on the most florid exa...
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Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due to the absence of suitable experimental models. Previously, we generated mice deficient in two intermediate filament (IF) proteins, glial fibrillary acidic protein (GFAP) and vimentin, whose upregulation is the hallmark of reactive astrocytes. GFAP(-/-)Vim(-/-) mice exhibit at...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2014
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2013.12.030